Review of the “ Public Health Goal for Perchlorate in Drinking Water ”
نویسنده
چکیده
I have reviewed the draft document dated January 11, 2011 as well as the online posted comments of external interested parties. I am an environmental epidemiologist with a primary research area outside of perchlorate and related health effects, but have done some work with perchlorate. I am pleased to have been given the opportunity to review this document and to offer some technical suggestions. In general, I will focus my comments on “4. The accuracy of the information regarding the new studies published since the 2004 perchlorate PHG “. However, in doing so, I will provide some suggestions regarding the “Developmental and Reproductive Toxicology” section.
منابع مشابه
Perchlorate PHG 01222013-ACWA Final Comments
The Association of California Water Agencies (ACWA) appreciates the opportunity to comment on the proposed public health goal (PHG) for perchlorate in drinking water. ACWA represents nearly 440 public water agencies in California that collectively supply 90% of the water delivered in California for domestic, agricultural and industrial uses. Our state enjoys some of the highest water quality in...
متن کاملتعیین غلظت پرکلرات در آب و خاک سطحی مناطق جنگی (مطالعه موردی: شهرستان خرمشهر)
Background and Objectives: Perchlorate, as an emerging contaminant, has attracted notice of the most individuals and organizations. Presence of perchlorate in the human body can lead to inappropriate regulation of metabolism in adults. Moreover, due to inhibition of iodide uptake in the thyroid gland, it causes neurological and behavioral problems in infants and children. United States Environm...
متن کاملDevelopment of a Health-Protective Drinking Water Level for Perchlorate
We evaluated animal and human toxicity data for perchlorate and identified reduction of thyroidal iodide uptake as the critical end point in the development of a health-protective drinking water level [also known as the public health goal (PHG)] for the chemical. This work was performed under the drinking water program of the Office of Environmental Health Hazard Assessment of the California En...
متن کاملIntersubject Variability of Risk from Perchlorate in Community Water Supplies
This article is a brief review and summary of the estimated incremental risks (increases in hazard quotient or decreases in thyroid uptake of iodine) to pregnant women (and hence their fetuses) associated with perchlorate exposure in community water supplies (CWSs) . The analysis draws on the recent health effects review published in 2005 by the National Research Council (NRC) . We focus on the...
متن کاملBasis of the Massachusetts Reference Dose and Drinking Water Standard for Perchlorate
OBJECTIVE Perchlorate inhibits the uptake of iodide in the thyroid. Iodide is required to synthesize hormones critical to fetal and neonatal development. Many water supplies and foods are contaminated with perchlorate. Exposure standards are needed but controversial. Here we summarize the basis of the Massachusetts (MA) perchlorate reference dose (RfD) and drinking water standard (DWS), which a...
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تاریخ انتشار 2011